Chemputability – Upfront Makeability Assessment
Chemify’s technology algorithmically scores each molecule’s Chemputability—its practical makeability—before synthesis begins. This upfront assessment reveals whether a design can be made and, if not, it suggests Chemputable alternatives, bridging the gap between design and make.
Context and Approach
For each partner’s molecule set, Chemify’s ASSEMBLER uses supervised learning for retrosynthesis and assembly-based forward analysis to define minimal construction pathways from validated building blocks and reaction classes. Routes are scored for Chemputability by comparing each step to Chemify’s expanding database of hundreds of reaction classes and hundreds of thousands of validated reactions — the largest digitized dataset of its kind.
ASSEMBLER ranks routes by platform efficiency, reaction certainty, step count, yield, and material cost, overcoming the unreliability of literature-based retrosynthesis and preventing costly synthetic failures.
Below are examples of our ASSEMBLER in action.
Retro and forward route generation
Chemputability scoring
Prioritized route ready for synthetic execution
Differentiating Features
We assess the makeability of every molecule before committing resources to synthesis, using only fully validated reactions that have been successfully run—not unverified literature procedures. If a molecule is not highly Chemputable, we suggest alternative structures that access the same chemical space and meet your target parameters while being readily synthesizable.
More Case Studies
Massive Library Derivatization Deep into Chemical Space
Once a synthetic route is established—even 15+ steps—our technology can repeatedly access and explore that region of chemical space, generating vast derivatized libraries for deep discovery.
Design Exquisite Molecules that are Makeable
Chemify’s Quantum Chemputation enables unbiased, synthesis-aware exploration of chemical space, directly producing real molecules with superior design, optimized properties, and synthetic tractability.
Let's Work Together
Collaboration with Chemify Starts Here
If you would like to know how makeable your molecules are before you commit or spend resources on attempting to synthesize, we would love to hear from you.
